Improving the symptoms of dysmenorrhea and menorrhagia of women with adenomyosis and myoma in short- and long-term treatment effectiveness of microwave ablation: A systematic review and meta-analysis

To identify improvement of symptoms of dysmenorrhea and menorrhagia of women who underwent treatment of Microwave ablation for adenomyosis and myoma. 463 articles were searched; 15 were included in the qualitative systematic review, and 13 were quantitively included in the meta-analysis and searched from TAYLOR FRANCIS, SCIENCE DIRECT, COCHRANE LIBRARY, WILLEY ONLINE LIBRARY, PUBMED. A total of 1123 of 652 women were diagnosed with adenomyosis, and 471 women were diagnosed with myoma. Studies were analyzed by pooling the weighted mean difference (WMD) with the 95 % CI in terms of study provided as a mean + (SD) and pooled results assessed with a random effect. Heterogeneity was evaluated using the I2 statistic. Visual analog scale (VAS) score and symptom severity scores (SSS) for adenomyosis was compared to post-microwave ablation (MWA) at 3,6, and 12 months showed significantly different heterogeneity with all statistically significant improved. Health-related quality of Life (HRQL) for adenomyosis were compared to post-MWA at 3,6, and 12 months showed significant improved. Hemoglobin (Hb) level for adenomyosis was compared to post-MWA at 3,6, and 12 months showed significantly different heterogeneity with all statistically significant increased the level of Hb. Hb level for myoma was compared to post-MWA and showed significantly different heterogeneity with no statistically significance. Myoma volumes were compared to post-MWA and showed significantly different heterogeneity with statistically significant reduced. Microwave ablation (MWA) is an effective and safe treatment for women with both adenomyosis and myoma in short- and long-term treatment and significantly improved symptoms and quality of life.