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Synapse
March 12, 20260 citations

Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS.

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DZDavid A ZidarMFMichael L. FreemanBWBrigid M Wilson

Key Points

  • To investigate the association between naïve CD4+ T lymphocyte deficiency and outcomes in heart failure.
  • Observational analysis of heart failure patients
  • Assessment of lymphocyte levels
  • Evaluation of mortality risk associated with lymphopenia
  • Heart failure patients displayed a significant deficiency of naïve CD4+ T lymphocytes
  • Total lymphopenia was noted in heart failure cases
  • Crude lymphopenia predicted higher mortality rates among the general population

Abstract

HF is associated with total lymphopenia due to a specific deficiency of naïve CD4+ T lymphocytes. Crude lymphopenia among the general ambulatory population can herald incident HF and poor subsequent survival.

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Cite This Study

Zidar et al. (2026) studied this question.

synapsesocial.com/papers/69b25abe96eeacc4fcec8b0bhttps://doi.org/10.1161/jaha.125.042475
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