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March 12, 2026The Journal of Immunology0 citations

Microalgal Delivery of Recombinant Interferon Enhances Antiviral Immunity in Fish

Microalgal delivery of recombinant fish interferon modulates gut microbiota and enhances antiviral immunity in fish

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Authors

GLGao-peng LiuZLZhuo-Cong LiQLQiyun Li

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Overview

Research reveals that recombinant interferon modulates gut microbiota and boosts immunity in fish, suggesting a new aquaculture strategy.

Key Points

  • Evaluate the effect of recombinant interferon delivery via microalgae on gut microbiota and antiviral immunity in fish.
  • Constructed recombinant interferon strain using Synechococcus sp. PCC 7002.
  • Administered Rec-IFN diet to gibel carp and zebrafish.
  • Analyzed intestinal microbiome and transcriptomic responses post-infection.
  • Rec-IFN diet promoted beneficial bacteria while reducing pathogens in gibel carp.
  • In zebrafish, the diet increased species richness and reduced Vibrio.
  • Enhanced host interferon response led to reduced viral load and mortality.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b25b5496eeacc4fcec9f57https://doi.org/10.1093/jimmun/vkaf304
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