What question did this study set out to answer?

This research aims to explore molecular mediators that connect genetically predicted BMI to breast cancer risk.

March 13, 2026Open Access

Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study

Key Points

This research aims to explore molecular mediators that connect genetically predicted BMI to breast cancer risk.
Two-sample Mendelian randomization study design
Analysis of genetic variants related to BMI
Assessment of CRP levels and their association with breast cancer risk
Higher genetically predicted BMI correlates with increased CRP levels
CRP levels may mediate the association between BMI and breast cancer
IGF-1 levels are identified as a potential attenuator of this relationship

Abstract

Chronic low-grade inflammation is a vital pathway linking genetically predicted BMI to breast cancer risk. Genetically predicted BMI is associated with higher genetically predicted CRP levels, potentially through a pathway involving reduced IGF-1 levels, which may attenuate the inverse association between genetically predicted BMI and breast cancer risk.

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Discussion

Authors

Yu Hao

Xia Jiang

Jinyu Xiao

Journals

BMC Cancer

Actions

Institutions

Karolinska Institutet

Sichuan University

West China Hospital of Sichuan University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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