Introduction: Scars are composed of fibrous tissue formed following full-thickness skin injury. Wound healing involves the coordinated activation of multiple biological pathways, with dermal collagen disruption triggering fibroblasts to deposit collagen bundles that restore tensile strength. This review outlines preoperative, intraoperative, and postoperative strategies to minimize scarring in cosmetic surgery. Materials and Methods: A literature review was performed and supplemented with clinical observations to identify techniques that optimize incision healing and reduce scar formation across the surgical timeline. Results: Preoperative strategies include optimizing nutrition—particularly protein intake to normalize serum albumin for collagen synthesis—and thoughtful incision planning to minimize scar risk. Intraoperatively, meticulous tissue handling, use of protective instruments (eg, port protectors in liposuction), and delayed-absorbable monofilament sutures (eg, polydioxanone) support optimal closure. Surgical tape can reduce track marks from external sutures, while compression garments help limit postoperative edema. Postoperative interventions include topical silicone, intense pulsed light therapy, intralesional corticosteroids or fluorouracil, and medical tattooing for scar camouflage. Scar revision procedures may be considered for unfavorable outcomes. Discussion: Successful scar minimization requires a comprehensive, staged approach. Preoperative preparation sets the foundation for healing, intraoperative techniques safeguard tissue integrity, and postoperative interventions help refine outcomes. Integrating these measures reduces scarring and enhances cosmetic results. Conclusion: Optimal management of surgical incision lines relies on coordinated preoperative, intraoperative, and postoperative strategies to promote wound healing and minimize scar formation.
Mowlavi et al. (Fri,) studied this question.