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March 13, 2026

Impact of GLP-1 Receptor Agonist Use on Total Knee Arthroplasty Outcomes in Metformin-Treated Diabetic Patients With and Without Comorbid Obesity: A Propensity-Matched Analysis

Key Points

Assess the impact of GLP-1 receptor agonist use on total knee arthroplasty outcomes in metformin-treated diabetic patients with and without obesity.
Propensity-matched analysis of metformin-treated T2DM patients undergoing total knee arthroplasty
Comparison of outcomes between GLP-1RA users and non-users
Evaluation of resource utilization and complications including aseptic loosening
GLP-1RA use reduced resource utilization in all patients
Obese patients experienced further reductions in medical complications
A lower rate of aseptic loosening was noted in the obese group

Abstract

Among metformin-treated T2DM patients undergoing TKA, GLP-1RA use was associated with reduced resource utilization irrespective of obesity. However, additional reductions in medical complications and aseptic loosening were observed in the obese group, suggesting a potential synergistic effect between weight loss and glycemic control. These findings highlight the effectiveness of GLP-1RAs in optimizing high-risk candidates undergoing TKA.

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Cite This Study

Lee et al. (Tue,) studied this question.

synapsesocial.com/papers/69b3ac1d02a1e69014ccd89e https://doi.org/https://doi.org/10.5435/jaaos-d-25-00982

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