Lower eGFR Associated With Decreased Total Testosterone in Males: Integrated Evidence From Cohorts to Real-World Data.

Key Points

• The aim is to explore the relationship between estimated glomerular filtration rate (eGFR) and testosterone levels in males.
• Analyzed integrated evidence from multiple cohorts and real-world data.
• Examined testosterone levels in relation to varying eGFR values.
• Observed testosterone changes post-renal function recovery in kidney transplant recipients.
• A clear linear-threshold relationship was found between decreasing eGFR and lower testosterone levels.
• Testosterone levels significantly increased after recovery of renal function in kidney transplant recipients.