Microtubule Quantum Effects and Thalamocortical Integration: A Multiscale Hypothesis for Consciousness

This record provides the preprint, simulation code, figures, and supplementary materials for the hypothesis paper: "Microtubule Quantum Effects and Thalamocortical Integration: A Multiscale Hypothesis for Consciousness." The paper proposes a multiscale framework for consciousness involving three interacting levels of biological organization: 1. Microtubule-level quantum-sensitive properties within neuronal cytoskeletal structures.2. Electrical oscillations and ionic soliton dynamics within microtubule networks acting as an electrodynamic transduction layer.3. Large-scale thalamocortical circuit integration supporting macroscopic neural oscillations associated with conscious experience. The hypothesis builds on experimental findings reporting intrinsic electrical oscillations in microtubules (~39 Hz) and theoretical models of nanopore-mediated ionic dynamics. Computational simulations explore whether aggregated microtubule voltages could plausibly influence neuronal network oscillations. The repository contains:- Python simulation scripts used in the computational analyses- Supplementary figures and modeling results- Supplementary materials associated with the manuscript GitHub repository:https://github.com/ozyurte/microtubule-thalamocortical-consciousness