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March 13, 2026Alzheimer s & Dementia0 citationsOpen Access

Zolpidem restores sleep and decreases amyloid in a mouse model

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LYLi YuSYShinya YokomizoTDTri H. Doan

Key Points

  • This research aims to investigate the effects of zolpidem on sleep patterns and amyloid levels in a mouse model relevant for Alzheimer's disease.
  • Administered zolpidem to young APP/PS1 mice.
  • Measured non-rapid eye movement (NREM) sleep stability and sleep fragmentation.
  • Assessed amyloid plaque burden and neuronal calcium levels.
  • Zolpidem improved NREM sleep stability and reduced fragmentation.
  • Restored slow oscillation in brain activity.
  • Reduced amyloid plaque burden and calcium overload in neurons.
  • Enhanced sleep-dependent memory consolidation in zolpidem-treated mice.

Abstract

Zolpidem treatment improves non-rapid eye movement (NREM) sleep stability and reduces sleep fragmentation. Zolpidem restores slow oscillation in young APP/PS1 (amyloid precursor protein/presenilin 1) mice. Zolpidem treatment reduces amyloid plaque burden and calcium overload in neurons. Zolpidem-treated mice show improved sleep-dependent memory consolidation. Sleep rhythm enhancement shows promise for Alzheimer's therapy.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69b3ace502a1e69014ccf04ahttps://doi.org/10.1002/alz.71175
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