To assess prognosis and clinical characteristics of SCN5A variant carriers with a negative sodium channel blocker challenge.
Multicentre analysis of SCN5A variant carriers
Inclusion of patients with negative sodium channel blocker challenge
Longitudinal monitoring for arrhythmic events
Excellent arrhythmic prognosis observed in carriers
Frequent progressive conduction slowing noted within the cohort
Largest analysis of its kind conducted
Abstract
This multicentre study provides the largest analysis of SCN5A carriers with negative SCBC, showing excellent arrhythmic prognosis despite frequent progressive conduction slowing.