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March 14, 2026Annals of Neurology0 citationsOpen Access

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

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NBNing BianChina University of Mining and TechnologyJSJianing ShenKunming University of Science and TechnologyLTLinwei TianKunming University of Science and Technology

Key Points

  • This research aims to assess the effects of astrocytic mitochondria transplantation in acute cerebral ischemic stroke models.
  • Utilized a mouse model of acute cerebral ischemic stroke
  • Performed astrocytic mitochondria transplantation
  • Evaluated neuronal survival and dendritic injuries
  • Transplantation improved neuronal survival in the stroke model
  • Restored bioenergetics in affected neurons
  • Demonstrated neuroprotective effects against dendritic injuries

Abstract

Astrocytic mitochondria transplantation is an effective therapeutic strategy for ischemic stroke. Its neuroprotective effects stem from the internalization of functional mitochondria into neurons and the subsequent flexibly regulation of endogenous mitochondrial dynamics, restoring bioenergetics and promoting neuronal survival. This approach holds significant promise for treating ischemic stroke and potentially other brain disorders involving mitochondrial dysfunction. ANN NEUROL 2026.

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Cite This Study

Bian et al. (2026) studied this question.

synapsesocial.com/papers/69b4b9eb18185d8a398023a7https://doi.org/10.1002/ana.78197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intercellular Mitochondrial Transfer as Endogenous Neuroprotection: Mechanisms and Therapeutic Implications in Ischemic Stroke2026
  2. 2Transplantation of astrocyte-derived mitochondria into injured astrocytes has a protective effect following stretch injury2024 · 3 citations
  3. 3Nature-Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes.2026 · 2 citations
  4. 4EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia2026
  5. 5Exogenous Functional Mitochondria Derived from Bone Mesenchymal Stem Cells That Respond to ROS Can Rescue Neural Cells Following Ischemic Stroke2024 · 4 citations