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March 14, 2026JAMA Ophthalmology0 citations

Bilateral Conversion Risk in Unilateral Retinoblastoma Using Age and Genetic Testing

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EDErkuan DaiHXHaodong XiaoRZRulian Zhao

Key Points

  • To explore how age and genetic testing inform the risk of bilateral conversion in unilateral retinoblastoma.
  • Analyzed age at diagnosis and genetic testing outcomes for unilateral retinoblastoma patients.
  • Identified subgroups based on RB1 variant status.
  • Assessed implications for surveillance and risk stratification.
  • RB1 variant-positive patients diagnosed after 9 months are low-risk for bilateral conversion.
  • Late conversions observed in RB1 variant-negative patients require ongoing monitoring.
  • Risk stratification can be enhanced using age-related data.

Abstract

The findings in this study suggest that age at diagnosis may refine genetic risk stratification for metachronous bilateral conversion. RB1 variant-positive patients diagnosed at 9 months or later represent a very low-risk subgroup that may warrant surveillance deescalation, while rare late conversions in RB1 variant-negative patients necessitate continued long-term monitoring.

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Cite This Study

Dai et al. (2026) studied this question.

synapsesocial.com/papers/69b4b9fb18185d8a39802504https://doi.org/10.1001/jamaophthalmol.2026.0143
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