Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation
Analysis explores acute kidney injury prevalence and mechanical ventilation risks in immunocompromised patients, indicating complexities in treatment decisions.
Key Points
This study aims to examine the prevalence of acute kidney injury (AKI) in immunocompromised patients experiencing acute respiratory failure and assess the risk linked to mechanical ventilation.
Post-hoc analysis of 734 immunocompromised patients from the HIGH clinical trial.
Evaluation of AKI prevalence and its association with mechanical ventilation.
Used causal inference models adjusted for the likelihood of requiring ventilation.
74% of patients developed AKI, while 41% required invasive mechanical ventilation.
AKI often occurred before ventilation, with the median peak KDIGO stage at 2 days.
Univariate analysis showed a significant association between ventilation and AKI, but not in multivariate analysis.