Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 14, 2026Neuro-Oncology PediatricsOpen Access

SURG-05. Evaluating liposomal topotecan for use in improving drug penetration within brain parenchyma for pediatric brain tumors

View Full Paper
Ask AI
Bookmark
Share

Authors

SNSasha NikiforovKBKathryn BlethenAEAngela Everhart

Discussion

Loading...

Member takes

Overview

Demonstrates improved drug penetration via LIFU in pediatric brain tumors, indicating a potential advance in treatment strategies.

Key Points

  • This research aims to evaluate the use of liposomal topotecan combined with low-intensity focused ultrasound to improve drug delivery to pediatric brain tumors.
  • Utilized low-intensity focused ultrasound (LIFU) to open the blood-brain barrier in a controlled manner.
  • Employed topotecan encapsulated in sonosensitive liposomes to enhance drug delivery.
  • Conducted in-situ brain perfusions in mice to evaluate drug uptake.
  • Assessed the pharmacodynamics of increased topotecan delivery in tumor models.
  • Liposomal topotecan showed varied uptake compared to free topotecan, with no linearity at specific time points.
  • The unidirectional uptake coefficient (Kin) for free topotecan was determined to be 4.9 ± 1.2x10-4 mL/s/g.
  • Increased drug accumulation was observed within LIFU-targeted tumor regions in preliminary mouse studies.

Cite This Study

Nikiforov et al. (2025) studied this question.

synapsesocial.com/papers/69b4fbd5b39f7826a300c545https://doi.org/10.1093/neuped/wuaf001.256
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850)2024 · 1 citations
  2. 2Abstract 500: Liposomal two-tailed topotecan (L-2TT) induces more apoptosis than topotecan hydrochloride on neuroblastoma xenografts2024 · 1 citations
  3. 3Development of Surfactant-Modified Liposomal Lomustine to Improve Blood–Brain Barrier Transport and Therapeutic Outcomes in Glioblastoma2026
  4. 4Blood-Brain Barrier Opening with Ultrasound Augments Doxorubicin and Anti-PD-1 Therapy Efficacy, Intracranial Immune Activation, and Prolongs Survival in Preclinical Glioma Models2024
  5. 5Unlocking the brain: Biodistribution insights into tween 80 nanoliposomes in healthy brains2026