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March 14, 2026Chemical Science0 citationsOpen Access

AccA from Neisseria gonorrhoeae provides a new framework for understanding periplasmic copper metallochaperones.

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SFSamantha J. FirthWEWilliam EarlDTDenis Thaqi

Key Points

  • The research aims to understand how AccA contributes to copper delivery in bacterial systems.
  • Analyzed copper trafficking mechanisms in Neisseria gonorrhoeae
  • Investigated the role of AccA in delivering copper to enzymes
  • Conducted biochemical assays to assess enzyme activity
  • AccA is crucial for efficient copper delivery to Cu-dependent enzymes
  • Disruption of AccA leads to impaired redox reactions
  • Enhanced understanding of copper utilization in bacterial energy metabolism

Abstract

Many bacteria use copper (Cu) to drive key redox reactions and energy metabolism, and they often rely on metallochaperones to deliver Cu to Cu-dependent enzymes. However, why trafficking by metallochaperones...

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Cite This Study

Firth et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbf9b39f7826a300c834https://doi.org/10.1039/d5sc08738d
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