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March 14, 2026PLoS ONEOpen Access

Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial

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Authors

APAlexandra PapaioannouCKCourtney KennedyJLJustin Lee

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Overview

Randomized controlled trial assesses the effectiveness of community frailty rehabilitation in older adults, suggesting potential for improved independence.

Key Points

  • The aim is to evaluate the effectiveness of community-based frailty rehabilitation on physical function among older adults living with frailty.
  • Multiarm, parallel-group, partially blinded, randomized controlled trial design
  • Participants: community-dwelling older adults aged ≥65 years with a FRAIL scale score of ≥2
  • Interventions: multimodal rehabilitation (group exercise, nutritional coaching) vs. exercise-only vs. control
  • Exercise classes twice weekly for 4 months with a tailored home exercise program
  • Primary outcome measured via the Short Performance Physical Battery and the 400m Walk Test.
  • Primary outcome: Improvement in physical function is anticipated in the multimodal group compared to others.
  • Secondary outcomes include positive changes in frailty, sarcopenia, cognition, and quality of life.
  • Cost-effectiveness analyses will support sustainable program development.

Cite This Study

Papaioannou et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc33b39f7826a300cec4https://doi.org/10.1371/journal.pone.0343338
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