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March 14, 2026PLoS ONE0 citationsOpen Access

Dosimetric comparison study of ultrahypofractionated photon versus proton treatment plans in post breast-conserving surgery breast cancer

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KSKitwadee SaksornchaiTTTanawat TawonwongPOPuntiwa Oonsiri

Key Points

  • This research compares dosimetric outcomes of ultrahypofractionated photon and proton treatment plans in breast cancer post-surgery.
  • Conducted a dosimetric comparison of IMPT (Intensity-Modulated Proton Therapy) and VMAT (Volumetric Modulated Arc Therapy) plans
  • Analyzed radiation doses to organs at risk (OARs) and assessed skin surface and esophageal doses
  • IMPT plans significantly reduced radiation exposure to surrounding organs at risk compared to VMAT
  • Noted an increase in skin surface dose with IMPT
  • Observed higher esophageal doses in certain cases when using IMPT

Abstract

IMPT plans significantly reduced radiation exposure to most surrounding OARs compared to VMAT. Clinical outcomes are needed to confirm the potential for reduced late toxicities. However, this benefit was accompanied by an increased skin surface dose and, in specific cases, a higher esophageal dose.

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Saksornchai et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc7fb39f7826a300d57ahttps://doi.org/10.1371/journal.pone.0344699
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