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March 14, 2026Cancer Medicine0 citationsOpen Access

Vitamin D and Bladder Cancer Risk: An Umbrella Review and Second Order Meta‐Analysis

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SMStefano MancinGFGaetano FerraraSPSara Morales Palomares

Key Points

  • The study aims to clarify the relationship between vitamin D levels and bladder cancer risk through a comprehensive review.
  • Conducted an umbrella review and second order meta‐analysis.
  • Assessed associations between serum vitamin D levels and bladder cancer risk.
  • Evaluated dietary intake and supplementation data.
  • Recommends standardized methods for vitamin D measurement.
  • Low serum vitamin D is consistently linked to higher bladder cancer risk.
  • Levels above 30 nmol/L may offer some protective effects.
  • Evidence on dietary intake and supplementation remains inconclusive.
  • Future research should address vitamin D measurement standards and population-specific differences.

Abstract

Low serum vitamin D is consistently associated with increased bladder cancer risk, while maintaining levels above 30 nmol/L may provide some protection. Evidence on dietary intake and supplementation remains inconclusive. Future studies should adopt standardized methods for vitamin D measurement, explore the role of free versus total vitamin D, and clarify population-specific differences to better define vitamin D's role in bladder cancer prevention.

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Cite This Study

Mancin et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc7fb39f7826a300d5f4https://doi.org/10.1002/cam4.71672
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