Cellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.This review synthesizes recent evidence detailing the accumulation of senescent cells in aged skeletal muscle, including muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), immune cells, endothelial cells, and even post-mitotic myofibers.Senescence in these cell types impairs regenerative signaling, disrupts niche homeostasis, and propagates chronic inflammation.Emerging therapeutic strategies, termed senotherapeutics, aim to counteract these effects through senolytics (which eliminate senescent cells) and senomorphics (which modulate the senescence-associated secretory phenotype), as promising interventions to restore muscle function and delay sarcopenia.We will also discuss the remaining challenges and future directions for studying senescence in skeletal muscle.
Building similarity graph...
Analyzing shared references across papers
Loading...
Yang Li
Huating WANG
Endocrinology and Metabolism
Chinese University of Hong Kong
Hong Kong Science and Technology Parks Corporation
Building similarity graph...
Analyzing shared references across papers
Loading...
Li et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69b5ff4f83145bc643d1b95e — DOI: https://doi.org/10.3803/enm.2025.2816