Development, anti-proliferative activity, multi-target kinase inhibition against CHK1, PIM1, and CDK-2, and computational insights of new thiazole-based hybrids

Key Points

• The research aims to develop thiazole-based hybrids with multi-target kinase inhibition.
• Targeting CHK1, PIM1, and CDK-2 in the design of new thiazole-based hybrids.
• Evaluation of anti-proliferative activity in cancer models.
• Computational analysis for insights on hybrid interactions.
• Successful development of thiazole-based hybrids with significant anti-proliferative activity.
• Inhibition of PIM1 identified as a key mechanism for cancer treatment.
• Computational insights highlight structural effectiveness of hybrids.

Abstract