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March 15, 2026

Efficacy and Safety of Pulsed Low-Dose Rate Radiotherapy in Re-Irradiation of Recurrent Solid Tumors

Key Points

This research examines the efficacy and safety of pulsed low-dose rate radiotherapy in recurrent solid tumors.
Evaluated pulsed low-dose rate radiotherapy (PLDR) for re-irradiation of recurrent solid tumors.
Analyzed patient characteristics such as IDH1 mutation status, recurrence location, and re-irradiation interval.
PLDR re-irradiation shows favorable efficacy and safety in recurrent solid tumors.
Patients with IDH1 mutation and nontemporal lobe recurrence benefit more from PLDR.
Longer re-irradiation intervals (>24 months) are associated with greater treatment advantages.

Abstract

PLDR re-irradiation demonstrates favorable efficacy and safety in recurrent solid tumors. For recurrent glioma, patients with IDH1 mutation, nontemporal lobe recurrence, and a re-irradiation interval >24 months appear to derive greater benefit from PLDR radiotherapy.

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Discussion

Authors

Xinyan Zhang

Zifang Liu

Huacong Jin

Journals

American Journal of Clinical Oncology

Actions

Institutions

Cancer Institute (WIA)

Jiangsu University

Xuzhou Medical College

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Efficacy and Safety of Pulsed Low-Dose Rate Radiotherapy in Re-Irradiation of Recurrent Solid Tumors

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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