A Systematic Review and Meta-Analysis of Pharmacological and Physical Interventions Directed at the Injection Site for Reducing Distress during Vaccine Injections | Synapse
March 15, 2026
A Systematic Review and Meta-Analysis of Pharmacological and Physical Interventions Directed at the Injection Site for Reducing Distress during Vaccine Injections
Puntos clave
To evaluate the effectiveness of pharmacological and physical interventions at the injection site for reducing distress during vaccine injections.
Conducted a systematic review and meta-analysis
Assessed various interventions including pharmacological agents and physical techniques
Collected evidence across different age groups for comprehensive analysis.
Topical anesthetics were identified as a preferred intervention for distress reduction
Manual skin tapping was noted as another effective technique
Findings suggest a need to align interventions with vaccine recipient preferences.
Resumen
Across all ages, topical anesthetics and manual skin tapping emerge as preferred interventions. Implementation should consider the strength of the evidence base as well as vaccine recipient preferences.