Biginelli Dihydropyrimidines: A Tunable Class of Alkyl Radical Precursors

Puntos clave

• This research aims to explore the synthesis of alkyl-substituted dihydropyrimidines as alternatives to existing compounds.
• Synthesis of alkyl-substituted dihydropyrimidines via the Biginelli reaction.
• Comparison with 4-alkyl Hantzsch dihydropyridines for radical chemistry applications.
• Systematic investigation of modularity in the synthesis process.
• Demonstrated the tunability of alkyl-substituted dihydropyrimidines for radical precursors.
• Showed potential advantages over traditional dihydropyridines in radical chemistry.