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March 15, 2026SHILAP Revista de lepidopterologíaOpen Access

Pregabalin and duloxetine combination for painful diabetic neuropathy: a systematic review and meta-analysis

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Authors

YSYifan ShiYCYuyang ChenHZHengxia Zhao

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Overview

Systematic review evaluates pain relief in diabetic neuropathy using combined pregabalin and duloxetine therapy, suggesting potential benefits.

Key Points

  • The aim is to assess the effectiveness of pregabalin combined with duloxetine for treating painful diabetic neuropathy.
  • Systematic searches of multiple databases for randomized controlled trials.
  • Assessment of methodological quality using the Cochrane risk-of-bias tool.
  • Statistical analyses performed using RevMan 5.4.
  • Combination therapy provided significantly greater pain relief than monotherapy with duloxetine.
  • Pain intensity, as measured by several scales, favored the combination therapy.
  • Higher percentages of patients achieved at least 50% pain reduction with the combination therapy compared to monotherapy.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69b64c33b42794e3e660d8b2https://doi.org/10.3389/fendo.2026.1750441
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the efficacy and safety of duloxetine and gabapentin in managing diabetic neuropathy: A systematic review and meta-analysis2025 · 4 citations
  2. 2Pregabalin and Duloxetine in Patients with Non-Nociceptive Pain: A Narrative Review Exploring the Pharmacological Effects of This Combination2025
  3. 3Amitriptyline, Pregabalin and Duloxetine for Treatment of Painful Diabetic Peripheral Neuropathy2024 · 1 citations
  4. 4Pregabalin as a Treatment for Painful Diabetic Peripheral Neuropathy: A Meta-Analysis2008 · 2 citations
  5. 5Efficacy of Pregabalin Alone and in Combination with Lacosamide in Pain Management of Diabetic Neuropathy2025