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March 15, 2026Frontiers in Cellular NeuroscienceOpen Access

Preclinical models of stem cell-mediated analgesia and tissue repair: mechanisms, challenges, and future directions

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Authors

MZMinshun ZhuHZH M ZhangLLLong Liang

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Overview

Narrative review evaluates mechanisms of stem cell therapy in pain relief and tissue repair, indicating key research avenues.

Key Points

  • This review aims to synthesize knowledge on the mechanisms of stem cell-mediated analgesia and regeneration.
  • Systematic review of literature from PubMed and Web of Science.
  • Focus on preclinical models related to pain and tissue regeneration.
  • Evaluation of methodological quality in selected studies.
  • Identified mechanisms of stem cell-mediated pain relief and tissue repair.
  • Highlighted heterogeneity in preclinical models affecting translation to clinical practice.
  • Discussed critical challenges and future directions in stem cell research.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69b64c33b42794e3e660d9d2https://doi.org/10.3389/fncel.2026.1787909
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