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March 15, 2026Clinical Toxicology0 citations

Toxicity Profile of Supratherapeutic Loperamide: Systematic Review and Dose-Response Analysis

Toxicity profile of supratherapeutic loperamide: a systematic review and dose–response analysis

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Authors

EBElias BekkaATAdrian Martinez-De la TorreMHManuel Haschke

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Overview

This systematic review analyzes dysrhythmias risk in patients with supratherapeutic loperamide exposure, suggesting the need for cardiac monitoring.

Key Points

  • Evaluate the toxicity and cardiac risks associated with supratherapeutic loperamide exposure.
  • Conducted a systematic review of available literature on loperamide toxicity.
  • Included dose-response analyses to assess the relationship between loperamide levels and cardiac events.
  • Examined management strategies for patients presenting with toxicity.
  • Patients with supratherapeutic loperamide levels were found to have a high incidence of life-threatening dysrhythmias.
  • Close cardiac monitoring was deemed essential for this high-risk population.
  • Management options identified include antiarrhythmic treatments and cardiocirculatory support.
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Bekka et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660dcd9https://doi.org/10.1080/15563650.2026.2634757
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