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March 15, 2026Scientific ReportsOpen Access

The role of BLZF1 in lung adenocarcinoma and its value as a diagnostic and prognostic biomarker

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Authors

CZChen ZhouZHZaoxiu HuTYTang Yu

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Overview

Study explores BLZF1's impact on lung adenocarcinoma, indicating its promise as a diagnostic biomarker.

Key Points

  • The study aims to investigate the role of BLZF1 in lung adenocarcinoma and its potential as a diagnostic and prognostic biomarker.
  • Analyzed 505 LUAD patients from TCGA and 60 from Yunnan Cancer Hospital.
  • Compared mRNA and protein expression levels of BLZF1 in cancer and para-cancer tissues.
  • Utilized ROC curves to assess BLZF1's diagnostic value.
  • Conducted survival analysis correlating BLZF1 levels with T stage and recurrence-free survival.
  • Downregulated BLZF1 using siRNA to study its effect on LUAD cell proliferation and migration.
  • BLZF1 expression was significantly higher in cancer tissues than in para-cancer tissues (P < 0.001).
  • In the TCGA dataset, the AUC for BLZF1 was 0.759, and 0.9985 in the clinical dataset (P < 0.0001 for both).
  • High BLZF1 expression correlated with decreased recurrence-free survival (HR = 1.510, P = 0.012) and overall survival (HR = 1.472, P = 0.010).
  • BLZF1 is associated with processes like Golgi function and glycolysis, indicating its role in sugar metabolism.
  • Knocking down BLZF1 expression inhibited LUAD cell proliferation, migration, and invasion.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660dcfahttps://doi.org/10.1038/s41598-026-40856-1
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