Aquaculture disease management, historically reliant on antibiotics and synthetic chemicals, requires sustainable and effective alternatives for microbial control.One of the strategies is by utilizing bioactive compound from natural product.However, the current method of extraction requires a huge amount of solvent and cause detrimental to the end product.Thus, this lead to extraction strategy using supercritical carbon dioxide (SC-CO 2 ) .This minireview explores the application of SC-CO 2 extraction as a green technology for disease management in aquaculture.SC-CO 2 operates as a clean, selective solvent, efficiently isolating high-purity bioactive compounds from plant, algal, and fishery by-products without toxic solvent residues.Unlike conventional extraction methods, SC-CO 2 preserves thermolabile antimicrobial compounds, yielding extracts with enhanced bioactivity against aquatic pathogens.By providing effective, natural alternatives to antibiotics, SC-CO 2 technology directly contributes to disease control in aquaculture.The integration of SC-CO 2 -derived natural products represents a transformative strategy for sustainable microbial control while aligning with the principles of environmental safety and food security.
Lal et al. (2026) studied this question.