The Cover illustrates the use of cGAS, a well-studied enzyme, as a promising biocatalyst for industrial applications. A bioprocess plant with a characteristic bioreactor represents scalable production, in which the enzyme cGAS catalyzes the formation of the cyclic dinucleotide cGAMP. The spotlight on the product molecule underscores the shift from fundamental biochemical research towards process development and biotechnological application. The image reflects the core theme of the Review by Makram Fataeri and Katrin Rosenthal (DOI: 10.1002/cbic.202500942) bridging the gap between molecular understanding and process-oriented implementation.
Fataeri et al. (2026) studied this question.