What question did this study set out to answer?

To evaluate the prognostic significance of ARID1A mutation and protein levels in endometrial cancer with no specific molecular profile.

March 16, 2026Open Access

The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

Puntos clave

To evaluate the prognostic significance of ARID1A mutation and protein levels in endometrial cancer with no specific molecular profile.
Conducted a retrospective analysis in a large Chinese cohort.
Examined correlations between ARID1A mutation and protein expression.
Analyzed associations with ER/PR expression and PIK3CA mutation status.
ARID1A mutation linked to poorer progression-free survival for NSMP patients.
ARID1A protein expression correlated significantly with ARID1A mutation status.
Combined ARID1A mutation and other markers could refine classification of NSMP subtype.

Resumen

ARID1A mutation was associated with worse PFS for patients with NSMP. ARID1A protein expression was significantly associated with ARID1A mutation. ARID1A mutation, with ER/PR expression and PIK3CA mutation status, could serve as the potential biomarkers to subclassify NSMP subtype and provide more precise therapeutic target.

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