Objectives: This study aimed to evaluate the diagnostic yield and complications associated with computed tomography (CT)-guided transthoracic core-needle biopsy (CNB) of lung lesions and to identify factors influencing biopsy outcomes. Methods: This retrospective study included patients who underwent CT-guided CNB of lung lesions at Sultan Qaboos Comprehensive Cancer Care P = 0.003). Lesion morphology, localisation, positron emission tomography guidance and patient demographics had no significant effects statistically. Complications in 28.8% of patients were largely pneumothorax (21.2%), followed by haemoptysis (8.7%) and haemothorax (1.9%). Smaller lesions (cm) and deeper locations (>5 cm) had higher rates of complications (P = 0.007 and P = 0.080, respectively). Conclusion: CT-guided lung biopsy demonstrated high diagnostic yield with acceptable rates of complications. Lesion depth and size had significant impacts on diagnostic success and occurrence of complications. These results support that CT-guided CNB is a safe and reliable diagnostic procedure for lung lesions, especially when lung lesions are superficially located and solid.
Sayani et al. (Fri,) studied this question.