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March 17, 2026Discover Oncology0 citationsOpen Access

Identification of a biologically coherent three gene immune signature predictive of immunotherapy benefit in gastric adenocarcinoma

RFRuihua FanJWJiru WangLXLijuan Xu

Key Points

  • To identify a biologically coherent three-gene immune signature that predicts the benefit of immunotherapy in gastric adenocarcinoma patients.
  • Developed a three-gene immune risk stratification signal (IRGPI) specific to gastric adenocarcinoma (GAC)
  • Analyzed associations with immune contexture and therapy-related signatures using computational methods
  • Assessed the robustness of gene-selection strategies for future validation
  • Identified a three-gene signature associated with patient responses to immunotherapy
  • Delineated relationships with computationally inferred immune contextures
  • Findings are hypothesis-generating for further validation in specifically treated gastric cancer cohorts

Abstract

This three-gene IRGPI provides a compact, biologically anchored risk stratification signal in GAC and is associated with computationally inferred immune contexture and therapy-related signatures. These associations are hypothesis-generating and require validation in treatment-annotated cohorts, particularly gastric cancer patients receiving immune checkpoint inhibitors; robustness to alternative gene-selection strategies should also be evaluated in future work.

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Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef52deb47d591b8c5573https://doi.org/10.1007/s12672-026-04831-6
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