To define COVID-19 endotypes and their implications for diagnosis and prognosis in patients.
Conducted unsupervised proteomic analysis
Identified biologically coherent endotypes
Analyzed the relationship between endotypes and acute lung injury
Identified distinct COVID-19 endotypes
Linked endotypes to improved diagnostic methods
Highlighted prognostic capabilities using routine blood tests
Abstract
Unsupervised proteomic analysis identified biologically coherent endotypes that advance understanding of acute lung injury in COVID‑19 and support improved diagnostic and prognostic strategies.