Analysis of CCN6 in the Context of Human Health and Disease: Current Insights and Unexplored Frontiers

ABSTRACT CCN6 is one of several proteins intimately linked with human health and disease, but not adequately studied. Here, we have described the diverse roles of CCN6 both as a secreted protein as well as in association with the mitochondria and nucleus, drawing probable correlations of the modular structural organization of CCN6 with its functions. In so doing, we have explained how the various structural and functional attributes of CCN6 could be linked with the maintenance of chondrocyte/cartilage and muscle health in the context of Progressive Pseudo Rheumatoid Dysplasia (PPRD), a musculoskeletal disorder caused by CCN6 mutations. Furthermore, we have outlined the significance of CCN6 in the context of cancers of the breast, colon, liver and stomach, and chondrosarcoma. Accordingly, we have evaluated and assembled several important aspects of CCN6 structure–function that demand contemplation for further research in the interest of a better understanding of CCN6 biology in relation to human health and disease.