What question did this study set out to answer?

To synthesize primary benzyl boronic acid pinacol esters using a one-carbon homologation strategy from aryl iodides.

March 18, 2026

Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

Key Points

To synthesize primary benzyl boronic acid pinacol esters using a one-carbon homologation strategy from aryl iodides.
Utilized a chloromethyl boron reagent with aryl iodides
Implemented a one-carbon homologation strategy
Conducted reactions under conditions accommodating diverse functional groups and heterocycles
Enabled gram-scale synthesis for practical applications
Achieved clean reaction profiles for synthesizing benzyl boronic esters
Expanded the range of accessible benzyl boronic esters beyond traditional methods
Facilitated versatile downstream transformations after synthesis

Abstract

Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.

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Authors

Ming Li

Jie Huang

Bo Zhang

Journals

The Journal of Organic Chemistry

Actions

Institutions

East China Normal University

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Building similarity graph...

Analyzing shared references across papers

Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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