Prospective evaluation of testosterone dose strategy in transgender individuals assigned female at birth: hormonal equivalence and psychological and behavioral outcomes

Key Points

• To evaluate the effectiveness of half- and full-dose testosterone strategies in transgender individuals assigned female at birth and their psychological outcomes.
• Prospective evaluation of two testosterone initiation strategies (half-dose and full-dose)
• Assessment of endocrine and clinical outcomes over 6 months
• Monitoring of impulsivity as a psychological outcome
• Half- and full-dose testosterone strategies resulted in comparable early endocrine outcomes
• Only transient differences in impulsivity were noted
• Emphasized the need for careful monitoring due to individual variability in responses

Abstract