B-cell monitoring predicts infection risk in childhood systemic lupus erythematosus patients on belimumab

Key Points

• The research aims to identify predictors of infection risk in childhood systemic lupus erythematosus patients undergoing treatment with belimumab.
• Analyzed the effects of belimumab on B cell depletion and immunoglobulin G levels.
• Developed a nomogram for risk stratification based on early B cell and IgG changes.
• Profound B cell depletion is associated with a higher infection risk.
• Significant reduction in IgG levels correlates with increased susceptibility to infections.
• The nomogram serves as a practical tool for monitoring and risk assessment.

Abstract