Connection Between Erectile Dysfunction and Dietary Index for Gut Microbiota: Results From NHANES 2001–2004

During past years, more attention has been paid to the gut microbiome’s effect on monitoring erectile dysfunction (ED). While the connection of the ED risk with dietary index for gut microbiota (DI‐GM) has not been sufficiently uncovered. This relationship was studied using data of NHANES from 2001 to 2004, with the DI‐GM estimated from dietary recall data. A total of 4116 individuals were enrolled in the study, of whom 1999 were diagnosed with ED. A negative relationship between ED risk and DI‐GM score was observed (OR: 0.87, 95% CI: 0.83–0.92). When DI‐GM scores were grouped, the scores in Q4 and Q3 were negatively correlated with ED in the adjusted model, with ORs (95% CI; p for trend) of 0.50 (0.39–0.65; <0.001) and 0.60 (0.45–0.80; <0.001), respectively, compared with the lowest quartile (Q1). Additionally, a nonlinear relationship between the prevalence of ED and DI‐GM score was revealed by restricted cubic spline (RCS) logistic analysis. The nomogram exhibited perfect performance (AUC 0.83, 95% CI = 0.81–0.84). In this study, DI‐GM score was negatively associated with ED risk, and the association was nonlinear.