CD8+ T cell migration is central to host defense, enabling clonal selection, tissue infiltration, and elimination of infected cells. While chemokines guide these cells by activating Rac for F-actin polymerization, recent studies reveal a complementary mechanism through Rho activation. This pathway relies on tissue confinement, which deforms the nucleus, activates the actomyosin network, and allows CD8+ T cells to use physical cues for surveillance without external signals. In this review article, we explore how chemokine- and mechanosensing-dependent pathways guide CD8+ T cell surveillance and introduce a 'front-' versus 'rear-driven' motility model to illustrate their integration for effective tissue monitoring. Ultimately, the interplay of biochemical and physical cues ensures tissue-specific protection by T cells during homeostasis and inflammation.
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Jens V. Stein
Heidi E. L. Lischer
Clara V I Palou
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Stein et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69ba42dc4e9516ffd37a377b — DOI: https://doi.org/10.48620/96118
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