SELFormer-Guided Discovery of Xanthohumol and Cirsilineol as Multi-Target Natural Therapeutics for Type 2 Diabetes: Computational Prediction and Experimental Validation

Key Points

• This research aims to discover and validate natural compounds that can address multiple targets in type 2 diabetes.
• Utilized computational prediction techniques for identifying potential therapeutic compounds.
• Focused on natural compounds Xanthohumol and Cirsilineol.
• Conducted experimental validation to assess effectiveness on insulin resistance and secretion.
• Xanthohumol and Cirsilineol demonstrated significant effects on both insulin resistance and secretion.
• Both compounds interacted with multiple targets, enhancing their therapeutic potential for type 2 diabetes.

Abstract