Integrating multi-omics technologies in traditional Chinese medicine: Novel insights into cancer therapy

Abstract Objectives: To explore the current applications and future prospects of multi-omics approaches in cancer therapy, with a focus on their integration into traditional Chinese medicine (TCM) for developing novel anti-tumor strategies. Methods: A comprehensive review of multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, microbiomics, single-cell omics, and spatial omics, was conducted, emphasizing their contributions to cancer research. The integration of multi-omics in TCM was also discussed, highlighting the challenges and further prospects associated with its modernization. Results: Multi-omics approaches have facilitated the identification of novel cancer biomarkers, therapeutic targets, and molecular subtypes, all of which are critical for advancing personalized cancer treatment. The integration of these omics approaches with TCM provides a powerful platform for elucidating the mechanisms underlying TCM-based therapies and developing innovative anti-cancer strategies. Conclusions: Multi-omics technologies are transforming the landscape of cancer treatment by offering deeper insights into tumor biology. The integration of these advanced approaches with TCM not only supports the modernization of traditional practices but also holds significant potential for improving cancer prevention and therapy. Continued interdisciplinary research is essential to overcome current limitations and to accelerate the translation of multi-omics and TCM integration into clinical practice.