The Effectiveness of Non-Biomedical Interventions for Thriving in HIV-Serodiscordant Relationships: A Mixed-Methods Protocol for a Study in Umguza District, Zimbabwe

HIV-serodiscordant couples face significant psychosocial and relational challenges that extend beyond biomedical management. While the role of Antiretroviral Therapy (ART) and Pre-Exposure Prophylaxis (PrEP) is well-established, the effectiveness of non-biomedical, psychosocial interventions in promoting relational thriving and overall well-being is under-researched, particularly in specific cultural contexts. This protocol describes a planned mixed-methods study designed to assess the effectiveness of existing interventions and explore the lived experiences of serodiscordant couples in Umguza District, Zimbabwe. The study will employ a sequential exploratory design comprising three phases: (1) a scoping review of interventions for thriving in serodiscordant relationships in Sub-Saharan Africa; (2) a quantitative cross-sectional survey with approximately 31 serodiscordant couples to map needs and assess perceived intervention effectiveness; and (3) in-depth qualitative interviews with a purposively selected subset of couples (n∼12) and healthcare workers (n∼12) to explore barriers, facilitators, and contextual dynamics. Data integration will occur during the interpretation phase to provide a comprehensive understanding. All participants will provide written informed consent, with stringent measures to ensure confidentiality and data security. Findings will be disseminated through peer-reviewed publications, presentations at relevant academic and community forums, and deposition of anonymised data in a public repository to promote transparency and reuse.