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March 18, 2026British Journal of Dermatology3 citationsOpen Access

Using biologic therapies as first-line systemic treatment for psoriasis: A cohort study following the target trial emulation framework from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR)

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DPDuc Binh PhanPLPhilip LawsCSCatherine H Smith

Key Points

  • To examine the impact of initiating biologics as first-line systemic therapy for psoriasis on clinical outcomes.
  • Cohort study design
  • Utilized data from the British Association of Dermatologists Biologics and Immunomodulators Register
  • Compared outcomes of biologic therapies versus standard stepwise treatments
  • Patients on biologics showed significantly better clinical outcomes than those on stepwise approaches
  • Findings indicate that earlier use of biologics can lead to improved health for psoriasis patients

Abstract

Initiating biologics as the first systemic therapy was associated with better clinical outcomes compared with standard stepwise approaches. These results support reconsideration of existing pathways to allow earlier use of biologics.

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Cite This Study

Phan et al. (2026) studied this question.

synapsesocial.com/papers/69ba43a84e9516ffd37a5104https://doi.org/10.1093/bjd/ljag098
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