Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study

Key Points

• This study aims to evaluate the safety and effectiveness of short antibiotic treatment for CoNS sepsis in premature infants.
• Conducted a multicenter noninferiority study
• Focused on premature infants with uncomplicated CoNS sepsis
• Compared short versus longer antibiotic treatment regimens
• Relapse rate in patients was less than 1%, indicating low risk of return of sepsis
• Short-course treatment was found to be noninferior to longer treatment
• Both treatment durations confirmed to be safe and effective