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March 19, 2026Basic & Clinical Pharmacology & Toxicology

Amantadine Enhances IL‐10 Expressions to Maintain the Renal Functions Against Inflammation and Oxidative Stress via Increasing PI3K/AKT/HIF‐1α Pathway and Decreasing AQP2–4 Signallings

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Authors

AKAlim KosarPKPinar Aslan KosarMTMuhammet Yusuf TEPEBAŞI

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Overview

Investigation shows amantadine improves kidney functions by enhancing IL-10 against inflammation, suggesting potential therapeutic benefits.

Key Points

  • The central aim is to examine how amantadine affects IL-10 levels and kidney function in the context of inflammation and oxidative stress.
  • Evaluated the effects of amantadine treatment on kidney tissue
  • Assessed IL-10 expression levels
  • Analyzed the involvement of PI3K/AKT/HIF-1α signaling pathways
  • Amantadine treatment increased IL-10 expressions in kidney tissue
  • Demonstrated anti-inflammatory effects through multiple pathways
  • Showed potential to protect renal functions against oxidative stress

Cite This Study

Kosar et al. (2026) studied this question.

synapsesocial.com/papers/69bb928c496e729e6297ff79https://doi.org/10.1111/bcpt.70216
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