PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
March 19, 2026Communications BiologyOpen Access

A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells

View Full Paper
Ask AI
Bookmark
Share

Authors

AHAanya HirdaramaniCCC. Yan ChengAHAylin C. Hanyaloglu

Discussion

Loading...

Member takes

Overview

Shows butyrate enhances PYY secretion in L-cells, indicating potential obesity treatments.

Key Points

  • The research aims to investigate how butyrate affects the identity and function of enteroendocrine L-cells via FFAR2 activation.
  • Utilized a human L-cell model to assess transcriptional and morphological changes.
  • Examined effects of butyrate on secretory profiles and Notch signaling in a mouse organoid model.
  • Applied the allosteric agonist AZ-1729 to evaluate its impact on PYY expression.
  • Butyrate stimulated a PYY-biased secretory profile in L-cells.
  • Increased expression of late-stage maturation markers NeuroD1 and Pax6 with butyrate.
  • AZ-1729 enhanced butyrate's effect on PYY and Pax6 upregulation.

Cite This Study

Hirdaramani et al. (2026) studied this question.

synapsesocial.com/papers/69bb92ae496e729e62980295https://doi.org/10.1038/s42003-026-09830-5
View Full Paper
Ask AI
Bookmark
Share