A structural blueprint for antibacterial discovery: microwave- and ultrasound-assisted synthesis of pyrrolidine-fused quinoxalines as novel inhibitors of DNA gyrase and biofilm
The research aims to discover new antibacterial agents that effectively inhibit DNA gyrase and combat biofilm formation.
Utilized microwave and ultrasound-assisted synthesis techniques for developing quinoxalines.
Investigated the structural properties of pyrrolidine-fused quinoxalines.
Conducted assays to evaluate the antibacterial efficacy against biofilm-forming microorganisms.
Identified novel inhibitors of DNA gyrase derived from the synthesized quinoxalines.
Demonstrated the effectiveness of these compounds in disrupting biofilm formation.
Showed potential for significant applications in treating infectious diseases.
Abstract
In order to lessen the severity of infectious diseases, anti-infective agents—drugs that prevent, combat, or control infections brought on by microorganisms—are essential in contemporary medicine.