Pd-catalyzed enantio-and diastereoselective synthesis of N-N atropisomeric indoles via N-alkylation reaction

Key Points

• This research aims to establish an effective method for synthesizing N-N axially chiral indoles using Pd-catalyzed N-alkylation.
• Pd-catalyzed N-alkylation reaction
• Focus on substrate tolerance and yield
• Assessment of enantio- and diastereoselectivity
• Achieved high enantioselectivity
• Demonstrated good substrate tolerance
• Reported significant diastereoselectivity in product formation