PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 19, 2026Chemical Science0 citationsOpen Access

A Brønsted Acid-Base Approach for the Net Monoselective C-F Substitution of (Trifluoromethyl)alkanes

NCNicholas James CoradiJBJeffrey S. Bandar

Key Points

  • The study aims to develop a method for selectively attaching nucleophiles to a single C-F bond in trifluoromethylalkanes.
  • Utilized a Brønsted acid-base approach for C-F substitution.
  • Involved a base-promoted reaction to facilitate dehydrofluorination.
  • Coupled nucleophiles through a nucleophilic addition cascade.
  • Achieved selective substitution on a single C-F bond.
  • Demonstrated significant potential for synthetic applications in organic chemistry.

Abstract

We disclose a method for the net coupling of nucleophiles with a single C-F bond of unactivated (trifluoromethyl)alkanes.The process occurs via an initial base-promoted dehydrofluorination/defluorinative nucleophilic addition cascade to generate...

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Coradi et al. (2026) studied this question.

synapsesocial.com/papers/69bb92be496e729e629803f8https://doi.org/10.1039/d6sc01042c
Ask AI
Helpful
Bookmark
Share
View Full Paper