Manipulation therapy alleviates neuropathic pain via the SOCS1 m 6 A epigenetic loop

Key Points

• The research aims to explore how manipulation therapy affects neuropathic pain through an epigenetic mechanism.
• Conducted experiments to evaluate the effects of manipulation therapy on neuropathic pain.
• Measured inflammation and RNA m6A methylation changes in the spinal cord.
• Utilized the SOCS1/TLR4 pathway as a focal point of investigation.
• Manipulation therapy significantly reduced levels of neuropathic pain.
• It altered inflammation markers in the spinal cord.
• m6A methylation was modified, linking epigenetic changes to pain relief.